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Denisovan Immunity Evidence Pipeline
A research-discovery compartment model for the Near Oceania Denisovan DNA story. It tracks candidate archaic variants as they move from unresolved ancestry signal to mapped Denisovan-like sequence, experimentally tested expression-modulating variants, and interpreted immune-pathway evidence. It does not model disease spread or individual medical risk.
Compartments
| Name | Color | Initial Fraction |
|---|---|---|
| Unresolved archaic candidates | — | 0.88 |
| Mapped Denisovan-like sequence | — | 0.1 |
| Expression-modulating variants | — | 0.02 |
| Interpreted immune-pathway signal | — | 0 |
Flows
| From | To | Rate |
|---|---|---|
| hidden | mapped | seq_rate * hidden |
| mapped | functional | assay_rate * mapped |
| functional | immune | interpret_rate * functional |
| immune | functional | review_rate * immune |
Parameters
| Name | Label | Default | Range |
|---|---|---|---|
| seq_rate | Rate at which under-sampled archaic signals become mapped sequence. | 0.035 | 0.005 – 0.1 |
| assay_rate | Rate at which mapped sequence receives direct functional testing. | 0.025 | 0.005 – 0.12 |
| interpret_rate | Rate at which functional variants become pathway-level evidence. | 0.018 | 0.003 – 0.08 |
| review_rate | Rate at which pathway claims return to the functional pool for review. | 0.006 | 0.001 – 0.03 |
User-Facing States
Unresolved archaic candidates hidden * N
Mapped Denisovan-like sequence mapped * N
Expression-modulating variants functional * N
Interpreted immune-pathway signal immune * N
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